Palladium-catalyzed aerobic (1+2) annulation of Csp3–H bonds with olefin for the synthesis of 3-azabicyclo[3.1.0]hex-2-ene. Issue 14 (6th February 2017)

• Record Type: Journal Article
• Authors: Wu, Kun; Meng, Lingkui; Huai, Mingming; Huang, Zhiliang; Liu, Chao; Qi, Xiaotian; Lei, Aiwen
• Is Part Of: Chemical communications. Volume 53:Issue 14(2017)
• Page Start: 2294
• Page End: 2297
• Publication Date: 2017-02-06
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc09332a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A novel Pd-catalyzed aerobic (1+2) annulation was developed and the palladation of Csp 3 –H bonds took place twice at the same position. Mechanistic studies by in situ IR revealed that the second C–H palladation and reductive elimination might be slow steps. Abstract : A novel palladium-catalyzed aerobic (1+2) annulation was developed for the synthesis of 3-azabicyclo[3.1.0]hex-2-ene. The palladation of Csp 3 –H bonds took place twice at the same position in the whole reaction process. Preliminary mechanistic studies by in situ IR revealed that the second C–H palladation and reductive elimination might be slow steps.