A novel withanolide with an unprecedented carbon skeleton from Physalis angulata. Issue 5 (18th January 2017)

• Record Type: Journal Article
• Authors: Sun, Cheng-Peng; Kutateladze, Andrei G.; Zhao, Feng; Chen, Li-Xia; Qiu, Feng
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 5(2017)
• Page Start: 1110
• Page End: 1114
• Publication Date: 2017-01-18
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob02656g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Aromaphysalin A (1 ), possessing an exceptional C(11)–C(15) bond and a rearranged 4, 9-cyclized aromatic ring, is isolated from of Physalis angulata . Abstract : A novel withanolide, aromaphysalin A (1 ), possessing an exceptional C(11)–C(15) bond and an unprecedented 4, 9-cyclized aromatic ring (ring A), is isolated from stems and leaves of Physalis angulata L. Its structure was determined by a combination of HRESIMS, 2D NMR spectra, and theoretical calculations. Compound1 exhibited inhibitory activity on NO production with an IC50 value of 51.64 μM. A plausible biosynthetic pathway for1 is also discussed.