Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor. Issue 5 (16th January 2017)

• Record Type: Journal Article
• Authors: Hanauer, Thomas; Hopkinson, Richard J.; Patel, Kamal; Li, Yu; Correddu, Danilo; Kawamura, Akane; Sarojini, Vijayalekshmi; Leung, Ivanhoe K. H.; Gruber, Tobias
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 5(2017)
• Page Start: 1100
• Page End: 1105
• Publication Date: 2017-01-16
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob02616h
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : We report a simple carboxycalixarene that selectively binds molecules containing di/trimethylammonium moieties in isolation, in cell lysates and when incorporated in histone peptides. Abstract : Chemical tools that recognise post-translational modifications have promising applications in biochemistry and in therapy. We report a simple carboxycalixarene that selectively binds molecules containing di/trimethylammonium moieties in isolation, in cell lysates and when incorporated in histone peptides. Our findings reveal the potential of using carboxycalixarene-based receptors to study epigenetic regulation.