A fast, highly selective and sensitive dansyl-based fluorescent sensor for copper (II) ions and its imaging application in living cells. Issue 10 (8th March 2017)

• Record Type: Journal Article
• Authors: Zhou, Ming; Wang, Xiaobo; Huang, Kunzhu; Huang, Yuzhao; Hu, Shou; Zeng, Wenbin
• Is Part Of: Tetrahedron letters. Volume 58:Issue 10(2017)
• Page Start: 991
• Page End: 994
• Publication Date: 2017-03-08
• Subjects: Fluorescent sensor -- Copper (II) ions -- Dansyl; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.01.090
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A novel fluorescent chemosensor1 for the detection of copper (II) ion was developed. 1 exhibited remarkable fluorescence quench for the sensitive and selective quantification of Cu 2+ . 1 showed an ultrafast and linear response towards Cu 2+ in wide range and can be used for detecting Cu 2+ in living cells. Abstract: Since the copper ions (Cu 2+ ) play a fatal role in many foundational physiological processes, it is important to develop a simple, highly sensitive and selective sensor for Cu 2+ detection in living systems. Herein, an intramolecular charge transfer (ICT) and dansyl-based fluorescent chemosensor1 was designed, synthesized and characterized for the sensitive and selective quantification of Cu 2+ . It exhibited remarkable fluorescence quenching upon addition of Cu 2+ over other selected metal ions, attributed to the complex formation between1 and Cu 2+ with the association constant 6.7 × 10 5 M −1 . The sensor1 showed a fast and linear response towards Cu 2+ in the concentration range from 0 to 12.5 × 10 −6 mol L −1 with the detection limit of 2.5 × 10 −7 mol L −1 . This detection could be carried out in a wide pH range of 5.0–14. Furthermore, sensor1 can be used for detecting Cu 2+ in living cells.