Anomalous subcortical morphology in boys, but not girls, with ADHD compared to typically developing controls and correlates with emotion dysregulation. (30th March 2017)

• Record Type: Journal Article
• Authors: Seymour, Karen E.; Tang, Xiaoying; Crocetti, Deana; Mostofsky, Stewart H.; Miller, Michael I.; Rosch, Keri S.
• Is Part Of: Psychiatry research. Volume 261(2017)
• Page Start: 20
• Page End: 28
• Publication Date: 2017-03-30
• Subjects: Attention-deficit/hyperactivity disorder -- Limbic -- Emotion -- Emotion regulation -- Subcortical; Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2017.01.002
• Languages: English
• ISSNs: 0925-4927

Abstract

Abstract: There has been limited investigation of volume and shape difference in subcortical structures in children with ADHD and a paucity of examination of the influence of sex on these findings. The objective of this study was to examine morphology (volume and shape) of subcortical structures and their association with emotion dysregulation (ED) in girls and boys with ADHD as compared to their typically-developing (TD) counterparts. Participants included 218 children ages 8–12 years old with and without DSM-IV ADHD. Structural magnetic resonance images were obtained, and shape analyses were conducted using large deformation diffeomorphic metric mapping (LDDMM). Compared to TD boys, boys with ADHD showed reduced volumes in the bilateral globus pallidus and amygdala. There were no volumetric differences in any structure between ADHD and TD girls. Shape analysis revealed localized compressions within the globus pallidus, putamen and amygdala in ADHD boys relative to TD boys, as well as significant correlations between increased ED and unique subregion expansion in right globus pallidus, putamen, and right amygdala. Our findings suggest a sexually dimorphic pattern of differences in subcortical structures in children with ADHD compared to TD children, and a possible neurobiological mechanism by which boys with ADHD demonstrate increased difficulties with ED. Highlights: Compared to typically-developing boys, boys with ADHD showed reduced volumes in the bilateral globus pallidus and amygdala. No differences in subcortical structure volumes were seen in girls with ADHD vs. typically-developing girls. Shape analysis revealed localized compressions within the globus pallidus, putamen and amygdala in ADHD boys relative to typically-developing boys. In boys with ADHD, there were significant correlations between increased emotion dysregulation and unique subregion expansion in right globus pallidus, putamen, and right amygdala.