Amygdala-prefrontal cortex resting-state functional connectivity varies with first depressive or manic episode in bipolar disorder. (22nd February 2017)

• Record Type: Journal Article
• Authors: Wei, Shengnan; Geng, Haiyang; Jiang, Xiaowei; Zhou, Qian; Chang, Miao; Zhou, Yifang; Xu, Ke; Tang, Yanqing; Wang, Fei
• Is Part Of: Neuroscience letters. Volume 641(2017)
• Page Start: 51
• Page End: 55
• Publication Date: 2017-02-22
• Subjects: First episode -- Depressive -- Manic -- Amygdala -- Prefrontal cortex -- Resting state -- Functional connectivity; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2017.01.052
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: This study used functional connectivity techniques to clarify mood state-related features. The individuals with BD were at their first elevated and depressed mood episode. To examine the amygdala-PFC neural system was to identify possible state-related neural system patterns at rest in BD. Abstract: Background: Bipolar disorder (BD) is one of the most complex mental illnesses, characterized by interactive depressive and manic states that are 2 contrary symptoms of disease states. The bilateral amygdala and prefrontal cortex (PFC) appear to play critical roles in BD; however, abnormalities seem to manifest differently in the 2 states and may provide further insight into underlying mechanisms. Methods: Sixteen participants with first-episode depressive and 13 participants with first-episode manic states of bipolar disorder as well as 30 healthy control (HC) participants underwent resting-state functional magnetic resonance imaging (fMRI). Resting-state functional connectivity (rsFC) between the bilateral amygdala and PFC was compared among the 3 groups. Results: Compared with depressive state participants of the BD group, manic state participants of the BD group showed a significant decrease in rsFC between the amygdala and right orbital frontal cortex (p < 0.05, corrected). In addition, rsFC between the amygdala and left middle frontal cortex was significantly decreased in depressive and manic state participants of the BD group when compared with the HC group (p < 0.05, corrected). Conclusions: Our findings suggest that mood state during the first episodes of BD may be related to abnormality in hemispheric lateralization. The abnormalities in amygdala- left PFC functional connectivity might present the trait feature for BD, while deficits in amygdala- right PFC functional connectivity might be specific to manic episode, compared to depressive episode.