Synchronous hepatic metastasis and metachronous Krukenberg tumor from advanced colon cancer. A case report with an unexpected disease-free survival. (2017)

• Record Type: Journal Article
• Authors: Li Destri, Giovanni; Puzzo, Lidia; Russo, Alessia Erika; Ferraù, Francesco; Di Cataldo, Antonio; Puleo, Stefano
• Is Part Of: International journal of surgery case reports. Volume 30(2017)
• Page Start: 138
• Page End: 141
• Publication Date: 2017
• Subjects: Advanced colorectal cancer -- Hepatic metastasis -- Krukenberg tumor -- Disease free survival -- Prognostic indexes -- Case report; Surgery -- Periodicals; Surgical Procedures, Operative -- Periodicals; Surgery; Electronic journals; Periodicals; 617.005
• DOI: 10.1016/j.ijscr.2016.11.044
• Languages: English
• ISSNs: 2210-2612

Abstract

Highlights: The prognosis of a colon cancer with hepatic and ovarian metastasis is very poor. A colon cancer patient with hepatic and ovarian metastases can heal. In the literature we have never found a similar case. An appropriate surgical approach, a tailored chemotherapy and an intensive follow-up are essential. The degree to which HIPEC may have had an impact is still unknown. Abstract: Background: In the international literature we have never found a long survival in patients treated for a colon cancer with synchronous hepatic metastases and for a metachronous Krukenberg tumor. Presentation of case: A 46-year old woman for an advanced colon cancer with a synchronous hepatic metastases was subjected to a left hemicolectomy and a resection of liver segment V (R0 resection; T4N2bM1; stage IVa according AJCC 2010). After one year a CT of the abdomen revealed an expansive formation of the left ovary. The patient was subjected to a bilateral ovariectomy, hysterectomy and hiperthermic intraperitoneal chemotherapy (HIPEC). The patient, after several cycles of adjuvant chemotherapy, is disease-free 13 years after surgery. Discussion: To our knowledge, in the literature there do not appear to be cases of such disease-free survival. The survival of patient despite the prognostic indexes is discussed. The authors discus the importance of an adequate surgical treatment especially for liver metastases simultaneously treated to colon cancer. The authors also focus on chemotherapy (FOLFOX and then FOLFIRI) performed in a pre-biological era. Furthermore, the degree to which the HIPEC may have had an impact is still unknown, although it seems to be the gold standard for the treatment of the microscopic peritoneal neoplastic remnant. Conclusion: The authors emphasize that the long term survival in colon cancer with hepatic and ovarian metastases is possible as long as it has an adequate surgical approach, a tailored chemotherapy and an intensive follow-up. Most likely new prognostic markers will have to be identified.