Protective effects of exercise training on endothelial dysfunction induced by total sleep deprivation in healthy subjects. (1st April 2017)

• Record Type: Journal Article
• Authors: Sauvet, Fabien; Arnal, Pierrick J; Tardo-Dino, Pierre Emmanuel; Drogou, Catherine; Van Beers, Pascal; Bougard, Clément; Rabat, Arnaud; Dispersyn, Garance; Malgoyre, Alexandra; Leger, Damien; Gomez-Merino, Danielle; Chennaoui, Mounir
• Is Part Of: International journal of cardiology. Volume 232(2017)
• Page Start: 76
• Page End: 85
• Publication Date: 2017-04-01
• Subjects: Endothelial function -- Inflammation -- Blood pressure -- Exercise training -- Sleep deprivation -- Blood flow; ACh acetylcholine -- BP blood pressure -- CVC cutaneous vascular conductance -- DAP diastolic arterial pressure -- HR heart rate -- HRR heart rate reserve -- ICAM-1 intracellular adhesion molecule-1 -- IL-6 interleukin-6 -- IMT intima media thickness -- MAP mean arterial pressure -- MCP-1 monocyte chemoattractant protein-1 -- Pmax maximal peak power at exercise -- PWV pulse wave velocity -- SAP systolic arterial pressure -- SkBF skin blood flow -- TNF-α tumor necrosis factor-alpha -- TSD total sleep deprivation -- VO2max maximal oxygen uptake; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2017.01.049
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: Sleep loss is a risk factor for cardiovascular events mediated through endothelial dysfunction. Aims: To determine if 7 weeks of exercise training can limit cardiovascular dysfunction induced by total sleep deprivation (TSD) in healthy young men. Methods: 16 subjects were examined during 40-h TSD, both before and after 7 weeks of interval exercise training. Vasodilatation induced by ACh, insulin and heat (42 °C) and pulse wave velocity (PWV), blood pressure and heart rate (HR) were assessed before TSD (controlday), during TSD, and after one night of sleep recovery. Biomarkers of endothelial activation, inflammation, and hormones were measured from morning blood samples. Results: Before training, ACh-, insulin- and heat-induced vasodilatations were significantly decreased during TSD and recovery as compared with the control day, with no difference after training. Training prevented the decrease of ACh-induced vasodilation related to TSD after sleep recovery, as well as the PWV increase after TSD. A global lowering effect of training was found on HR values during TSD, but not on blood pressure. Training induces the decrease of TNF-α concentration after TSD and prevents the increase of MCP-1 after sleep recovery. Before training, IL-6 concentrations increased. Cortisol and testosterone decreased after TSD as compared with the control day, while insulin and E-selectin increased after sleep recovery. No effect of TSD or training was found on CRP and sICAM-1. Conclusions: In healthy young men, a moderate to high-intensity interval training is effective at improving aerobic fitness and limiting vascular dysfunction induced by TSD, possibly through pro-inflammatory cytokine responses.(ClinicalTrial:NCT02820649 ) Highlights: Sleep deprivation triggers endothelial dysfunction and inflammatory response. Exercise training prevents endothelial dysfunction induced by sleep deprivation. Exercise training could be considered as a relevant countermeasure to sleep deprivation. Protective effect of exercise training is linked to inflammatory responses. Graphical abstract: