Glyco-functionalized dinuclear rhenium(i) complexes for cell imaging. Issue 7 (30th January 2017)
- Record Type:
- Journal Article
- Title:
- Glyco-functionalized dinuclear rhenium(i) complexes for cell imaging. Issue 7 (30th January 2017)
- Main Title:
- Glyco-functionalized dinuclear rhenium(i) complexes for cell imaging
- Authors:
- Palmioli, Alessandro
Aliprandi, Alessandro
Septiadi, Dedy
Mauro, Matteo
Bernardi, Anna
De Cola, Luisa
Panigati, Monica - Abstract:
- Abstract : New luminescent glycosilated rhenium complexes were synthesized and evaluated as dyes for optical imaging. Abstract : The design, synthesis and photophysical characterization of four new luminescent glycosylated luminophores based on dinuclear rhenium complexes, namely Glyco-Re, are described. The derivatives have the general formula [Re2 (μ-Cl)2 (CO)6 (μ-pydz-R)] (R-pydz = functionalized 1, 2-pyridazine), where a sugar residue (R) is covalently bound to the pyridazine ligand in the β position. Different synthetic pathways have been investigated including the so-called neo-glycorandomization procedure, affording stereoselectively glyco-conjugates containing glucose and maltose in a β anomeric configuration. A multivalent dinuclear rhenium glycodendron bearing three glucose units is also synthesized. All the Glyco-Re conjugates are comprehensively characterized and their photophysical properties and cellular internalization experiments on human cervical adenocarcinoma (HeLa) cells are reported. The results show that such Glyco-Re complexes display interesting bio-imaging properties, i.e. high cell permeability, organelle selectivity, low cytotoxicity and fast internalization. These findings make the presented Glyco-Re derivatives efficient phosphorescent probes suitable for cell imaging application.
- Is Part Of:
- Organic & biomolecular chemistry. Volume 15:Issue 7(2017)
- Journal:
- Organic & biomolecular chemistry
- Issue:
- Volume 15:Issue 7(2017)
- Issue Display:
- Volume 15, Issue 7 (2017)
- Year:
- 2017
- Volume:
- 15
- Issue:
- 7
- Issue Sort Value:
- 2017-0015-0007-0000
- Page Start:
- 1686
- Page End:
- 1699
- Publication Date:
- 2017-01-30
- Subjects:
- Chemistry, Organic -- Periodicals
Bioorganic chemistry -- Periodicals
Chemistry, Physical organic -- Periodicals
547 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/ob#!recentarticles&all ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c6ob02559e ↗
- Languages:
- English
- ISSNs:
- 1477-0520
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 6286.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 1775.xml