Effect of polyester/PEG mixed micelles composition on preparation of multicompartment nanoparticles: Influence of crystallinity on morphology. (February 2017)

• Record Type: Journal Article
• Authors: Khoee, Sepideh; Mousazadeh, Mohammad; Bagheri, Yousef
• Is Part Of: European polymer journal. Volume 87(2017:Feb.)
• Page Start: 286
• Page End: 299
• Publication Date: 2017-02
• Subjects: Mucoadhesion -- Multicompartment -- Pentablock copolymer -- Mixed micelles -- Drug delivery; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; Polymerization; Polymers; Periodicals; Electronic journals; 547.705
• DOI: 10.1016/j.eurpolymj.2016.12.028
• Languages: English
• ISSNs: 0014-3057

Abstract

Graphical abstract: Highlights: Two triblock copolymers were synthesized via condensation polymerization. Polymers were fully characterized by FT-IR, 1 H NMR and DSC methods. Mixed micelles with different ratios of copolymers were prepared by nano-precipitation method. Mucoadhesion properties and drug release of nanoparticles were studied. Abstract: In this study, the overall morphology of a mixture of two types of pentablock copolymers was studied. Poly(butylene adipate)-polyethylene glycol (PBA/PEG) and poly(diethyleneglycol adipate)-polyethylene glycol (PDEGA/PEG) dendritic copolymers have been prepared by condensation polymerization. PDEGA-PEG and PBA-PEG mixed micelles were synthesized via nanoprecipitation method and the effect of copolymer composition on morphology, stability, drug loading, in vitro release, and mucoadhesion property of nanoparticles was evaluated. It was found that by changing the composition of two pentablocks in the binary mixed micelles, their morphology and their inner structure can be definitely tuned from uniform mixed micelle to multicompartment one. In vitro mucoadhesion and drug release profile of the nanoparticles were investigated and it was observed that mixing of the two copolymers with specific characteristics can provide a useful situation for preparation of nanocarriers with unique properties for practical applications.