Adult NSC diversity and plasticity: the role of the niche. (February 2017)

• Record Type: Journal Article
• Authors: Llorens-Bobadilla, Enric; Martin-Villalba, Ana
• Is Part Of: Current opinion in neurobiology. Volume 42(2017)
• Page Start: 68
• Page End: 74
• Publication Date: 2017-02
• Subjects: Neurobiology -- Periodicals; 573.8
• DOI: 10.1016/j.conb.2016.11.008
• Languages: English
• ISSNs: 0959-4388

Abstract

Highlights: NSCs are a heterogeneous pool of cells. Niche signals govern the diversity of NSCs. The injury niche alters the homeostatic lineage relationships. Abstract : Adult somatic stem cells are generally defined as cells with the ability to differentiate into multiple different lineages and to self-renew during long periods of time. These features were long presumed to be represented in one single tissue-specific stem cell. Recent development of single-cell technologies reveals the existence of diversity in fate and activation state of somatic stem cells within the blood, skin and intestinal compartments [1 ] but also in the adult brain. Here we review how recent advances have expanded our view of neural stem cells (NSCs) as a diverse pool of cells and how the specialized microenvironment in which they reside acts to maintain this diversity. In addition, we discuss the plasticity of the system in the injured brain.