Photoactive meso-tetra(4-pyridyl)porphyrin-tetrakis-[chloro(2, 2′bipyridine)platinum(ii) derivatives recognize and cleave DNA upon irradiation. Issue 5 (18th January 2017)

• Record Type: Journal Article
• Authors: Oliveira, Vanessa A.; Iglesias, Bernardo A.; Auras, Bruna L.; Neves, Ademir; Terenzi, Hernán
• Is Part Of: Dalton transactions. Volume 46:Issue 5(2017)
• Page Start: 1660
• Page End: 1669
• Publication Date: 2017-01-18
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/c6dt04634g
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : Photoactive platinum porphyrins may be interesting as photosensitizers in photodynamic therapy and photochemotherapy, and we demonstrate their activity towards DNA cleavage under exposure to light. Abstract : In this work, we evaluate the interaction of the peripheral Pt(bpy)Cl + substituted porphyrins, H2 PtPor andZnPtPor with DNA using UV-vis, emission fluorescence, CD spectroscopy, and DNA melting properties altered by the Pt(ii )–porphyrinoid compounds. Additionally, we observe the ability of these porphyrin derivatives to generate 1 O2 and to efficiently photocleave plasmid DNA upon visible light irradiation based on a mixed (oxidative/hydrolytic) mechanism.