Drug–DNA complexation as the key factor in photosensitized thymine dimerization. Issue 7 (2nd February 2017)

• Record Type: Journal Article
• Authors: Cuquerella, M. Consuelo; Lhiaubet-Vallet, Virginie; Miranda, Miguel A.; Bosca, Francisco
• Is Part Of: Physical chemistry chemical physics. Volume 19:Issue 7(2017)
• Page Start: 4951
• Page End: 4955
• Publication Date: 2017-02-02
• Subjects: Chemistry, Physical and theoretical -- Periodicals; 541.3
• DOI: 10.1039/c6cp08485k
• Languages: English
• ISSNs: 1463-9076

Abstract

Abstract : The crucial role of photosensitizer@DNA complexation in the formation of cyclobutane pyrimidine dimers (CPDs) has been demonstrated using femtosecond and nanosecond transient absorption and emission measurements in combination with in vitro DNA damage assays. Abstract : The crucial role of photosensitizer@DNA complexation in the formation of cyclobutane pyrimidine dimers (CPDs) has been demonstrated using femtosecond and nanosecond transient absorption and emission measurements in combination with in vitro DNA damage assays. This finding opens the door to re-evaluate the mechanisms involved in CPDs photosensitized by other chemicals.