An enyne cycloisomerization/[5+1] reaction sequence to synthesize tetrahydroisoquinolinones from enyne-enes and CO. Issue 13 (31st January 2017)

• Record Type: Journal Article
• Authors: Zhuang, Zhe; Li, Chen-Long; Xiang, Yu; Wang, Yu-Hao; Yu, Zhi-Xiang
• Is Part Of: Chemical communications. Volume 53:Issue 13(2017)
• Page Start: 2158
• Page End: 2161
• Publication Date: 2017-01-31
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc09925d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An enyne cycloisomerization/[5+1] reaction sequence was developed to synthesize tetrahydroisoquinolinones from linear enyne-enes and CO. Abstract : An enyne cycloisomerization/[5+1] reaction sequence was developed to synthesize tetrahydroisoquinolinones from linear enyne-enes and CO. The first step is a gold(i )-catalyzed enyne cycloisomerization, generating six-membered-ring-fused vinylcyclopropanes. The second step is a rhodium(i )-catalyzed [5+1] reaction of vinylcyclopropanes with CO. This two-step reaction could also be carried out in one-pot without isolating the cycloisomerization product generated from the first step of this sequence.