Self-assembly of ultra-small micelles from amphiphilic lipopeptoids. Issue 13 (1st February 2017)

• Record Type: Journal Article
• Authors: Lau, King Hang Aaron; Castelletto, Valeria; Kendall, Thomas; Sefcik, Jan; Hamley, Ian W.; Reza, Mehedi; Ruokolainen, Janne
• Is Part Of: Chemical communications. Volume 53:Issue 13(2017)
• Page Start: 2178
• Page End: 2181
• Publication Date: 2017-02-01
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc09888f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Self-assembly of peptoids was directed with a lipid tail to form ultra-small and stable micelles as a basis for peptidomimetic nanospheres. Abstract : Poly( N -substituted glycine) "peptoids" constitute a promising class of peptide-mimetic materials. We introduce the self-assembly of lipopeptoids into spherical micelles ca. 5 nm in diameter as well as larger assemblies by varying the peptoid sequence design. Our results point to design rules for the self-assembly of peptoid nanostructures, enabling the creation of stable, ultra-small peptidomimetic nanospheres.