Preloading of Hydrophobic Anticancer Drug into Multifunctional Nanocarrier for Multimodal Imaging, NIR‐Responsive Drug Release, and Synergistic Therapy. Issue 46 (27th September 2016)

• Record Type: Journal Article
• Authors: Wang, Hui; Wang, Kui; Tian, Bowei; Revia, Richard; Mu, Qingxin; Jeon, Mike; Chang, Fei‐Chien; Zhang, Miqin
• Is Part Of: Small. Volume 12:Issue 46(2016)
• Page Start: 6388
• Page End: 6397
• Publication Date: 2016-09-27
• Subjects: hydrophobic drugs -- mesoporous silica -- multifunctional imaging -- preloading -- synergistic effects; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201602263
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Applications of hydrophobic drug‐based nanocarriers (NCs) remain largely limited because of their low loading capacity. Here, development of a multifunctional hybrid NC made of a magnetic Fe3O4 core and a mesoporous silica shell embedded with carbon dots (CDs) and paclitaxel (PTX), and covered by another layer of silica is reported. The NC is prepared via a one‐pot process under mild condition. The PTX loading method introduced in this study simplifies drug loading process and demonstrates a high loading capacity due to mesoporous silica dual‐shell structure, supramolecular π‐stacking between conjugated rings of PTX molecules, and aromatic rings of the CDs in the hybrid NC. The CDs serve as both confocal and two‐photon fluorescence imaging probes, while the Fe3O4 core serves as a magnetic resonance imaging contrast agent. Significantly, NC releases PTX in response to near infrared irradiation as a result of local heating of the embedded CDs and the heating of CDs also provides an additional therapeutic effect by thermally killing cancer cells in tumor in addition to the chemotherapeutic effect of released PTX. Both in vitro and in vivo results show that NC demonstrates high therapeutic efficacy through a synergistic effect from the combined chemo‐photothermal treatments. Abstract : A new nanocarrier (NC) comprised of a magnetic Fe3 O4 core, fluorescent carbon dots, preloaded hydrophobic drug paclitaxel, and mesoporous silica for optical bioimaging, magnetic resonance imaging, and near infrared‐responsive drug release is reported in this manuscript. Results demonstrate that the hybrid NCs have high therapeutic efficacy through synergistic effect due to the combined chemo‐photothermal treatments.