Mild and Direct Multiple Deuterium‐Labeling of Saturated Fatty Acids. Issue 20 (31st August 2016)

• Record Type: Journal Article
• Authors: Yamada, Tsuyoshi; Park, Kwihwan; Yasukawa, Naoki; Morita, Kosuke; Monguchi, Yasunari; Sawama, Yoshinari; Sajiki, Hironao
• Is Part Of: Advanced synthesis & catalysis. Volume 358:Issue 20(2016)
• Page Start: 3277
• Page End: 3282
• Publication Date: 2016-08-31
• Subjects: deuterium -- fatty acids -- isopropyl alcohol -- platinum on carbon -- valproic acid; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201600363
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: We have established a mild and direct platinum on carbon (Pt/C)‐catalyzed multi‐deuterium labeling of various saturated fatty acids including bioactive compounds with high deuterium efficiencies in a mixed solvent of isopropyl alcohol and deuterium oxide ( i‐ PrOH)/D2 O under neutral conditions at 120 °C without the external addition of deuterium or hydrogen gas. Abstract :