A meta-analysis of sperm donation offspring health outcomes. (30th August 2016)

• Record Type: Journal Article
• Authors: Adams, D. H.; Clark, R. A.; Davies, M. J.; de Lacey, S.
• Is Part Of: Journal of developmental origins of health and disease. Volume 8:Number 1(2017)
• Page Start: 44
• Page End: 55
• Publication Date: 2016-08-30
• Subjects: Donor conception, -- meta-analysis, -- neonate, -- outcome, -- sperm; Developmental biology -- Periodicals; Embryology, Human -- Periodicals; Disease susceptibility -- Periodicals; Prenatal influences -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; 612.64
• DOI: 10.1017/S2040174416000489
• Languages: English
• ISSNs: 2040-1744

Abstract

Abstract : Although the use of donor sperm as a treatment modality for male infertility has become common place, the health outcomes for those conceived has been poorly studied. A structured search of the literature using PubMed, EMBASE and Cochrane Reviews was performed to investigate the health outcomes of offspring conceived from donor sperm. Eight studies were eligible and included in the review, and of these, three were included in a meta-analysis. Meta-analysis of clinical outcomes showed that donor sperm neonates are not at increased risk of being born of low birth weight (<2500 g), preterm (<37 weeks) or with increased incidences of birth defects, than spontaneously conceived neonates.