Association of a gain‐of‐function variant in LGR4 with central obesity. Issue 1 (7th December 2016)

• Record Type: Journal Article
• Authors: Zou, Yaoyu; Ning, Tinglu; Shi, Juan; Chen, Maopei; Ding, Lin; Huang, Ya; Kauderer, Sophie; Xu, Min; Cui, Bin; Bi, Yufang; Liu, Simin; Hong, Jie; Liu, Ruixin; Ning, Guang; Wang, Jiqiu
• Is Part Of: Obesity. Volume 25:Issue 1(2017)
• Page Start: 252
• Page End: 260
• Publication Date: 2016-12-07
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.21704
• Languages: English
• ISSNs: 1930-7381

Abstract

Abstract : Objective: To determine the relationship of the gain‐of‐function variant A750T in leucine‐rich repeat containing G protein‐coupled receptor 4 ( LGR4 ) with central obesity and related metabolic phenotypes. Methods: The LGR4 A750T (c.2248 G > A) variant was detected by Sanger sequencing in a discovery young population and a validation community‐based population with obesity from eastern China. Fat indices determined by anthropometry and computed tomography scans and clinical biochemical measurements were collected for association analysis. Results: LGR4 A750T was significantly correlated with waist circumference ( P = 0.030) and waist‐to‐height ratio ( P < 0.001) in the young cohort ( N = 594) and with waist‐to‐hip ratio ( P = 0.013) in the community population ( N = 1067). Combined analysis showed a significant correlation of the variant with waist circumference ( P < 0.001) and waist‐to‐hip ratio ( P = 0.021). Moreover, the variant had a remarkable correlation with abdominal visceral fat area ( P = 0.004) and was associated with 2‐h plasma insulin ( P = 0.009) and the Matsuda index ( P = 0.027) after an oral glucose tolerance test in young subjects with obesity. Conclusions: The LGR4 A750T variant may contribute to central obesity characterized by abdominal visceral fat accumulation.