Polymer‐based monolithic column with incorporated chiral metal–organic framework for enantioseparation of methyl phenyl sulfoxide using nano‐liquid chromatography. Issue 23 (18th November 2016)

• Record Type: Journal Article
• Authors: Wang, Xin; Lamprou, Alexandros; Svec, Frantisek; Bai, Yu; Liu, Huwei
• Is Part Of: Journal of separation science. Volume 39:Issue 23(2016)
• Page Start: 4544
• Page End: 4548
• Publication Date: 2016-11-18
• Subjects: Chiral stationary phases -- Enantioselectivity -- Nano‐liquid chromatography -- Metal‐organic frameworks -- Polymer monoliths; Separation (Technology) -- Periodicals; Chromatographic analysis -- Periodicals; 543.089
• DOI: 10.1002/jssc.201600810
• Languages: English
• ISSNs: 1615-9306

Abstract

Abstract : A new approach to the preparation of enantioselective porous polymer monolithic columns with incorporated chiral metal–organic framework for nano‐liquid chromatography has been developed. While no enantioseparation was achieved with monolithic poly(4‐vinylpyridine‐co‐ethylene dimethacrylate) column, excellent separations of both enantiomers of (±)‐methyl phenyl sulfoxide were achieved with its counterpart prepared after admixing metal–organic framework [Zn2 (benzene dicarboxylate)(l‐lactic acid)(dmf)], which is synthesized from zinc nitrate, l ‐lactic acid, and benzene dicarboxylic acid in the polymerization mixture. These novel monolithic columns combined selectivity of the chiral framework with the excellent hydrodynamic properties of polymer monoliths, may provide a great impact on future studies in the field of chiral analysis by liquid chromatography.