New streptophenazines from marine Streptomyces sp. 182SMLY. Issue 4 (16th February 2017)

• Record Type: Journal Article
• Authors: Liang, Ying; Chen, Lu; Ye, Xuewei; Anjum, Komal; Lian, Xiao-Yuan; Zhang, Zhizhen
• Is Part Of: Natural product research. Volume 31:Issue 4(2017)
• Page Start: 411
• Page End: 417
• Publication Date: 2017-02-16
• Subjects: Streptomyces sp. 182SMLY -- (-)-streptophenazines M–O -- (-)-streptophenazine B -- antibacterial activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2016.1169419
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Six phenazines including three new ones were isolated from the culture of a marine actinomycete Streptomyces sp. 182SMLY. Based on the analyses of NMR, HRESIMS, optical rotation value, and CD data, the structures of these isolated compounds were determined as new phenazines of (-)-streptophenazines M–O and known phenazines of 1-carbomethoxyphenazine and (-)-streptophenazines A and B. (-)-Streptophenazine B showed activity in suppressing the growth of methicillin-resistant Staphylococcus aureus with MIC value of 4.2 μg/mL. Abstract :