Anticancer, Azonafide‐Inspired Fluorescent Ligands and Their Rhenium(I) Complexes for Cellular Imaging. Issue 3 (24th January 2017)

• Record Type: Journal Article
• Authors: Langdon‐Jones, Emily E.; Jones, Ariana B.; Williams, Catrin F.; Hayes, Anthony J.; Lloyd, David; Mottram, Huw J.; Pope, Simon J. A.
• Is Part Of: European journal of inorganic chemistry. Issue 3(2017)
• Page Start: 759
• Page End: 766
• Publication Date: 2017-01-24
• Subjects: Fluorescence -- Cell imaging -- Rhenium -- Azonafide -- N ligands -- Cancer; Chemistry, Inorganic -- Periodicals; Organometallic chemistry -- Periodicals; Bioinorganic chemistry -- Periodicals; Solid state chemistry -- Periodicals; 546
• DOI: 10.1002/ejic.201601271
• Languages: English
• ISSNs: 1434-1948

Abstract

Abstract : Two dipicolyamino‐conjugated anthracene‐1, 9‐dicarboximide fluorophores and their corresponding Re I complexes have been synthesised and photophysically examined. All species were fluorescent in the visible region at about 490 nm with lifetimes up to 16 ns. The anticancer potency of the ligands and complexes was demonstrated across a range of cancer cell lines (LOVO, PC3, A549, MCF‐7). Cell imaging studies with MCF7 cells and Schizosaccharomyces pombe show that these fluorophores exhibit variable intracellular localisation patterns that are structure‐dependent. Abstract : Fluorescent anthracene‐1, 9‐dicarboximide derivatives have been developed as ligands for Re I . The ligands and complexes show anticancer behaviour and can be applied to fluorescence cell imaging with MCF7 and Schizosaccharomyces pombe cells.