Synthesis and Photophysical Properties of Triazolyl IrIII Nucleosides. Issue 3 (19th January 2017)

• Record Type: Journal Article
• Authors: Passays, Johan; Rubay, Christophe; Marcélis, Lionel; Elias, Benjamin
• Is Part Of: European journal of inorganic chemistry. Issue 3(2017)
• Page Start: 623
• Page End: 629
• Publication Date: 2017-01-19
• Subjects: Iridium -- Nucleosides -- Click chemistry -- DNA -- Polypyridyl complex; Chemistry, Inorganic -- Periodicals; Organometallic chemistry -- Periodicals; Bioinorganic chemistry -- Periodicals; Solid state chemistry -- Periodicals; 546
• DOI: 10.1002/ejic.201601227
• Languages: English
• ISSNs: 1434-1948

Abstract

Abstract : DNA‐based nanomaterials are the subject of numerous researches. A series of modified nucleobases were synthesized either to construct a double helix where the natural H‐bonded bases are replaced by metal‐coordinated liganosides or to introduce a punctual modification inside a natural DNA structure. Thanks to their photophysical and photochemical properties, iridium(III) complexes are of increasing interest in the development of sensors and photoreactants for biochemical applications. In this view, we previously demonstrated that some Ir III complexes are able to photoreact with DNA through photoinduced electron transfer. In this study, we report the synthesis and characterization of nucleosides bearing iridium complexes with unaltered properties compared to their parent complexes. Abstract : Iridium(III) complexes are of increasing interest in the development of sensors and photoreactants for biochemical applications. In our group, we previously demonstrated that some Ir III complexes are able to photoreact with DNA through photoinduced electron transfer. In this article, we report the synthesis and characterization of nucleoside–iridium conjugates.