Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma: A meta-analysis. Issue 49 (December 2016)

• Record Type: Journal Article
• Authors: Zhang, Shizhen; Wang, Zhen; Shan, Jinlan; Yu, Xiuyan; Li, Ling; Lei, Rui; Lin, Daozhe; Guan, Siqi; Wang, Xiaochen
• Other Names: Hsu. Ching-Sheng section editor.
• Is Part Of: Medicine. Volume 95:Issue 49(2016)
• Publication Date: 2016-12
• Subjects: β-catenin -- colorectal cancer -- meta-analysis -- prognosis; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000005546
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Background: The differential subcellular localizations of β-catenin (including membrane, cytoplasm, and nucleus) play different roles in the progression of colorectal cancer (CRC). However, the correlation between each subcellular localization of β-catenin and the prognosis of CRC patients remains undetermined. Methods: Systematic strategies were applied to search for eligible published studies in the PubMed, Embase, and Web of Science databases. The correlation between each subcellular localizations of β-catenin expression and patients' clinicopathological features or prognosis was analyzed. Results: Finally, this meta-analysis, including 6238 cases from 34 studies, revealed that β-catenin overexpression in the nucleus (HR: 1.50[95% CI: 1.08–2.10]) or reduced expression of β-catenin in the membrane (HR: 1.33[95% CI: 1.15–1.54]) significantly correlated with lower 5-year overall survival (OS). Conversely, overexpression of β-catenin in the cytoplasm (HR: 1.00[95% CI: 0.85–1.18]) did not show significant association with 5-year OS. Conclusion: This study suggested that β-catenin overexpression in the nucleus or reduced expression in the membrane, but not its overexpression in cytoplasm, could serve as a valuable prognostic predictor for CRC. However, additional large and well-designed prospective studies are required to verify our results. Abstract : Supplemental Digital Content is available in the text