Underlying undiagnosed inherited marrow failure syndromes among children with cancer. Issue 2 (31st August 2016)

• Record Type: Journal Article
• Authors: Alabbas, Fahad; Weitzman, Sheila; Grant, Ronald; Bouffet, Eric; Malkin, David; Abla, Oussama; Dror, Yigal
• Is Part Of: Pediatric blood & cancer. Volume 64:Issue 2(2017)
• Page Start: 302
• Page End: 305
• Publication Date: 2016-08-31
• Subjects: bone marrow failure -- cancer; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.26120
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: To study the prevalence of pediatric cancer patients who have underlying inherited bone marrow failure syndrome (IBMFS), we retrospectively reviewed the medical records of newly diagnosed pediatric cancer patients at The Hospital for Sick Children from June 2009 to May 2010, focusing on clinical, laboratory, and treatment‐related findings which may indicate underlying IBMFS. We found five (1.8%) patients out of 276 who had two or more findings suggestive of IBMFS. We conclude that a small fraction of patients with cancer have clinical features that indicate investigations to rule out underlying IBMFSs. A prospective study is needed to determine their prevalence.