Multiple contrast type tests for the evaluation of animal carcinogenicity studies. Issue 1 (2nd January 2017)

• Record Type: Journal Article
• Authors: Rahman, Mohammad; Tiwari, Ram
• Is Part Of: Journal of biopharmaceutical statistics. Volume 27:Issue 1(2017)
• Page Start: 175
• Page End: 185
• Publication Date: 2017-01-02
• Subjects: Animal carcinogenicity study -- Cochran–Armitage test -- dose–response relationship -- multiple contrast test; Pharmacy -- Statistical methods -- Periodicals; Drugs -- Testing -- Statistical methods -- Periodicals; Biometry -- Periodicals; Biopharmaceutics -- Periodicals; Pharmacokinetics -- Periodicals; 615.19
• DOI: 10.1080/10543406.2016.1148708
• Languages: English
• ISSNs: 1054-3406

Abstract

ABSTRACT: The Cochran–Armitage (CA) test is frequently used for testing the dose–response relationship in tumor incidence. This test is based on a weighted linear regression of proportions. It is well known that the CA test lacks power for nonlinear tumor outcomes. For general shape of outcomes, Hothorn and Bretz (2000) proposed a multiple contrast (MC) test. This test suggests the use of the maximum over several single contrasts, where each of them is chosen appropriately to cover a specific dose–response shape. In this work, two new test procedures are proposed and they are compared to the CA and MC tests using power.