Fluorogenic probes to monitor cytosolic phospholipase A2 activity. Issue 11 (20th January 2017)

• Record Type: Journal Article
• Authors: Ng, Cheng Yang; Kwok, Timothy Xiong Wei; Tan, Francis Chee Kuan; Low, Chian-Ming; Lam, Yulin
• Is Part Of: Chemical communications. Volume 53:Issue 11(2017)
• Page Start: 1813
• Page End: 1816
• Publication Date: 2017-01-20
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc09305a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Functionalization on the alkyl tail of arachidonyl trifluoromethylketone leads to the development of fluorogenic inhibitor and substrate probes of cPLA2 . Abstract : Arachidonic acid derivatives equipped with either one or two fluorescent groups attached to the tip of the alkyl chains were synthesized and shown to function as inhibitor and substrate probes of cPLA2 . The inhibitor probe was demonstrated to perform dual functions of inhibition and imaging while the substrate probe could be used for activity assay.