Frontispiece: Metal Complexes for Two‐Photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two‐Photon Photosensitization of Cancer Cells under Near‐IR Light. Issue 2 (5th January 2017)

• Record Type: Journal Article
• Authors: McKenzie, Luke K.; Sazanovich, Igor V.; Baggaley, Elizabeth; Bonneau, Mickaële; Guerchais, Véronique; Williams, J. A. Gareth; Weinstein, Julia A.; Bryant, Helen E.
• Is Part Of: Chemistry. Volume 23:Issue 2(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-01-05
• Subjects: cancer therapy -- iridium -- singlet oxygen -- transition metals -- two-photon photodynamic therapy; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201780262
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Complexes for Photodynamic Therapy In their Communication onpage 234 ff., J. A. Weinstein, H. E. Bryant et al. present two low‐molecular‐weight, long‐lived and photo‐stable iridium complexes of the [Ir(N C)2 (N N)] + family which have high two‐photon absorption and localise to mitochondria and lysosomal structures. Both are efficient photosensitizers (PS) under 1‐photon irradiation resulting in apoptotic death in cancer cell lines at low light doses, low concentrations, and high photo‐indices. Complex1 also displays high PS activity under NIR two‐photon excitation, which along with its photo‐stability indicates potential future clinical application.