Cobalt‐Catalyzed Reductive Multicomponent Synthesis of β‐Hydroxy‐ and β‐Aminocarbonyl Compounds under Mild Conditions. Issue 2 (29th November 2016)

• Record Type: Journal Article
• Authors: Paul, Jérôme; Presset, Marc; Cantagrel, Frédéric; Le Gall, Erwan; Léonel, Eric
• Is Part Of: Chemistry. Volume 23:Issue 2(2017)
• Page Start: 402
• Page End: 406
• Publication Date: 2016-11-29
• Subjects: aryl halides -- cobalt -- homogeneous catalysis -- hydroxycarbonyl compounds -- multicomponent reactions; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201604251
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: The cobalt‐catalyzed multicomponent reaction between sp 2 ‐hybridized organic halides, Michael acceptors, and unsaturated electrophiles has been developed. The reaction proceeds through a formal conjugate addition/aldol or aza‐aldol (Mannich) tandem reaction initiated by the in situ metalation of the organic halide by cobalt catalysis. The essentially new reaction conditions that have been developed are very mild and atom‐economic. Under these conditions, a broad range of β‐hydroxy‐ and β‐aminocarbonyl compounds are obtained in good to high yields. Abstract : Mild but not weak : A cobalt‐catalyzed three‐component reaction that provides β‐hydroxycarbonyl compounds and some nitrogenated counterparts is described. The reaction is characterized by mild and atom‐economic conditions, which allow the use of sensitive electrophilic species (see scheme).