A flexible route to bioactive 6-alkyl-α-pyrones. Issue 9 (1st March 2017)

• Record Type: Journal Article
• Authors: Qu, Yang; Kraus, George A.
• Is Part Of: Tetrahedron letters. Volume 58:Issue 9(2017)
• Page Start: 892
• Page End: 893
• Publication Date: 2017-03-01
• Subjects: 6-Chloro-α-pyrone -- Bioactive -- Malonate -- Common intermediate -- Double decarboalkoxylation; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.01.063
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Development of a common intermediate for the synthesis of three biologically active pyrones. One-pot double decarboalkoxylation of pyrone malonates. Reaction scope expanded to 3-chloroisocoumarine. Abstract: Both 6-chloro-α-pyrones and 3-chlorobenzopyran-1-ones react with malonates followed by a double decarboalkoxylation to give the corresponding alkyl and alkenyl products.