A facile synthesis of 1-oxo-pyrrolo[2, 1-a]isoquinolines. Issue 9 (1st March 2017)

• Record Type: Journal Article
• Authors: Voskressensky, Leonid G.; Borisova, Tatiana N.; Matveeva, Maria D.; Khrustalev, Viktor N.; Titov, Alexander A.; Aksenov, Alexander V.; Dyachenko, Svetlana V.; Varlamov, Alexey V.
• Is Part Of: Tetrahedron letters. Volume 58:Issue 9(2017)
• Page Start: 877
• Page End: 879
• Publication Date: 2017-03-01
• Subjects: Pyrrolo[2, 1-a]isoquinolines -- Activated alkynes -- Lamellarin; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.01.061
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A novel approach towards polysubstituted pyrrolo[2, 1- a ]isoquinolines was developed. Migration of the aryl group accompanies the target molecule formation. Functional groups of the products can be used for further modification. Abstract: The facile synthesis of 1-oxo-pyrrolo[2, 1- a ]isoquinolines from the reaction of 1-aroyl-3, 4-dihydroisoquinolines and symmetrical alkynes in toluene is described. The novel compounds contain functional groups that are suitable for further modification.