Palladium-mediated synthesis of 1, 1, 2-triarylethanes. Application to the synthesis of CDP-840. Issue 9 (2nd March 2017)
- Record Type:
- Journal Article
- Title:
- Palladium-mediated synthesis of 1, 1, 2-triarylethanes. Application to the synthesis of CDP-840. Issue 9 (2nd March 2017)
- Main Title:
- Palladium-mediated synthesis of 1, 1, 2-triarylethanes. Application to the synthesis of CDP-840
- Authors:
- Lin, Yi-Shan
Kuo, Yi-Chun
Kuei, Chun-Hsiung
Chang, Meng-Yang - Abstract:
- Abstract: A three-step protocol toward 1, 1, 2-triarylethanes1 starting with β-ketosulfones2 is developed. A facile process is carried out for the (1) reduction of2 with NaBH4, (2) BF3 ·OEt2 -mediated Friedel-Crafts reactions of the resulting β-hydroxy sulfones3, and (3) palladium-catalyzed desulfonylative cross-coupling of the corresponding5 with aryl iodides4 in the presence of t -BuOK under warming DMF in acceptable yields. A facile synthesis of CDP-840 (1v ) has been studied. Graphical abstract:
- Is Part Of:
- Tetrahedron. Volume 73:Issue 9(2017)
- Journal:
- Tetrahedron
- Issue:
- Volume 73:Issue 9(2017)
- Issue Display:
- Volume 73, Issue 9 (2017)
- Year:
- 2017
- Volume:
- 73
- Issue:
- 9
- Issue Sort Value:
- 2017-0073-0009-0000
- Page Start:
- 1275
- Page End:
- 1282
- Publication Date:
- 2017-03-02
- Subjects:
- 1, 1, 2-Triarylethanes -- Desulfonative cross-coupling -- CDP-840
Chemistry, Organic -- Periodicals
547.005 - Journal URLs:
- http://www.elsevier.com/journals ↗
- DOI:
- 10.1016/j.tet.2017.01.030 ↗
- Languages:
- English
- ISSNs:
- 0040-4020
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8796.850000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 714.xml