Drug resistance mechanisms and novel drug targets for tuberculosis therapy. (20th January 2017)

• Record Type: Journal Article
• Authors: Islam, Md Mahmudul; Hameed, H.M. Adnan; Mugweru, Julius; Chhotaray, Chiranjibi; Wang, Changwei; Tan, Yaoju; Liu, Jianxiong; Li, Xinjie; Tan, Shouyong; Ojima, Iwao; Yew, Wing Wai; Nuermberger, Eric; Lamichhane, Gyanu; Zhang, Tianyu
• Is Part Of: Journal of genetics and genomics. Volume 44:Number 1(2017)
• Page Start: 21
• Page End: 37
• Publication Date: 2017-01-20
• Subjects: Tuberculosis -- Mycobacterium tuberculosis -- Resistance -- Drug target -- Mechanism; Genetics -- Periodicals; Genomics -- Periodicals; 576.505
• DOI: 10.1016/j.jgg.2016.10.002
• Languages: English
• ISSNs: 1673-8527

Abstract

Abstract: Drug- resistant tuberculosis (TB) poses a significant challenge to the successful treatment and control of TB worldwide. Resistance to anti- TB drugs has existed since the beginning of the chemotherapy era. New insights into the resistant mechanisms of anti- TB drugs have been provided. Better understanding of drug resistance mechanisms helps in the development of new tools for the rapid diagnosis of drug- resistant TB. There is also a pressing need in the development of new drugs with novel targets to improve the current treatment of TB and to prevent the emergence of drug resistance in Mycobacterium tuberculosis . This review summarizes the anti- TB drug resistance mechanisms, furnishes some possible novel drug targets in the development of new agents for TB therapy and discusses the usefulness using known targets to develop new anti- TB drugs. Whole genome sequencing is currently an advanced technology to uncover drug resistance mechanisms in M. tuberculosis . However, further research is required to unravel the significance of some newly discovered gene mutations in their contribution to drug resistance.