PLC-β1 and cell differentiation: An insight into myogenesis and osteogenesis. (January 2017)

• Record Type: Journal Article
• Authors: Ramazzotti, Giulia; Faenza, Irene; Fiume, Roberta; Billi, Anna Maria; Manzoli, Lucia; Mongiorgi, Sara; Ratti, Stefano; McCubrey, James A.; Suh, Pann-Ghill; Cocco, Lucio; Follo, Matilde Y.
• Is Part Of: Advances in biological regulation. Volume 63(2017)
• Page Start: 1
• Page End: 5
• Publication Date: 2017-01
• Subjects: Cellular control mechanisms -- Periodicals; Biological control systems -- Periodicals; Molecular biology -- Periodicals; Periodicals; 571.74
• DOI: 10.1016/j.jbior.2016.10.005
• Languages: English
• ISSNs: 2212-4926

Abstract

Abstract: Phosphoinositide-phospholipase C-β1 (PLC-β1) plays a crucial role in the initiation of the genetic program responsible for muscle differentiation and osteogenesis. During myogenic differentiation of murine C2C12 myoblasts, PLC-β1 signaling pathway involves the Inositol Polyphosphate Multikinase (IPMK) and β-catenin as downstream effectors. By means of c-jun binding to cyclin D3 promoter, the activation of PLC-β1 pathway determines cyclin D3 accumulation. However, osteogenesis requires PLC-β1 expression and up-regulation but it does not affect cyclin D3 levels, suggesting that the two processes require the activation of different mediators.