Branched Gold Nanoparticle Coating of Clostridium novyi‐NT Spores for CT‐Guided Intratumoral Injection. Issue 5 (15th November 2016)

• Record Type: Journal Article
• Authors: Park, Wooram; Cho, Soojeong; Huang, Xiaoke; Larson, Andrew C.; Kim, Dong‐Hyun
• Is Part Of: Small. Volume 13:Issue 5(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-11-15
• Subjects: bacteriolytic tumor therapy -- Clostridium novyi‐NT -- computed tomography image‐guided therapy -- gold nanoparticles; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201602722
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Branched gold nanoparticle (BGNP)‐coated Clostridium novyi‐ NT ( C. novyi ‐NT) spores are developed for computed tomography (CT)‐guided bacteriolytic tumor therapy. The BGNP‐coated spores are successfully injected into a tumor site under CT image guidance. As a result, a strong antitumor effect is observed in a PC3 prostate tumor‐bearing mouse model.