A one-pot synthesis of omarigliptin and its analogues through stabilized beta-amino ketone intermediate. Issue 4 (16th February 2017)
- Record Type:
- Journal Article
- Title:
- A one-pot synthesis of omarigliptin and its analogues through stabilized beta-amino ketone intermediate. Issue 4 (16th February 2017)
- Main Title:
- A one-pot synthesis of omarigliptin and its analogues through stabilized beta-amino ketone intermediate
- Authors:
- Li, You
Liu, Tongchao
Li, Chungang
Xiong, Bing
Zhao, Dongmei
Cheng, Maosheng
Chen, Guohua
Shen, Jingkang
Chen, Yue-Lei - Abstract:
- ABSTRACT: We have discovered a unique stabilization condition for beta -amino ketone7 . With compound7 as an unprecedented intermediate, omarigliptin1 could be prepared in a highly efficient one-pot procedure with good yield. Also with this intermediate7, some analogues of omarigliptin1 were readily prepared for the first time. GRAPHICAL ABSTRACT:
- Is Part Of:
- Synthetic communications. Volume 47:Issue 4(2017)
- Journal:
- Synthetic communications
- Issue:
- Volume 47:Issue 4(2017)
- Issue Display:
- Volume 47, Issue 4 (2017)
- Year:
- 2017
- Volume:
- 47
- Issue:
- 4
- Issue Sort Value:
- 2017-0047-0004-0000
- Page Start:
- 357
- Page End:
- 363
- Publication Date:
- 2017-02-16
- Subjects:
- Beta-amino ketone -- omarigliptin -- one pot synthesis -- reductive amination -- stabilization effect
Organic compounds -- Synthesis -- Periodicals
Chemistry, Organic
Synthesis
547.205 - Journal URLs:
- http://www.tandfonline.com/toc/lsyc20/current ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/00397911.2016.1265129 ↗
- Languages:
- English
- ISSNs:
- 0039-7911
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8586.830000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 2492.xml