Regioselective synthesis and antimicrobial evaluation of some thioether–amide linked 1, 4-disubstituted 1, 2, 3-triazoles. Issue 4 (16th February 2017)

• Record Type: Journal Article
• Authors: Kaushik, C. P.; Pahwa, Ashima; Thakur, Rajesh; Kaur, Pawan
• Is Part Of: Synthetic communications. Volume 47:Issue 4(2017)
• Page Start: 368
• Page End: 378
• Publication Date: 2017-02-16
• Subjects: 1, 2, 3-triazoles -- 1, 4-disubstitued -- antibacterial activity -- antifungal activity -- click reaction; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2016.1265983
• Languages: English
• ISSNs: 0039-7911

Abstract

ABSTRACT: A series of 1, 4-disubstituted 1, 2, 3-triazoles having thioether as well as amide linkage were synthesized from aryl(prop-2-yn-1-yl)sulfanes and 2-azido- N -substituted acetamides through Cu(I) catalyzed click reaction. Structures of newly synthesized compounds (3a –3x ) were confirmed by spectral techniques like FTIR, 1 H NMR, 13 C NMR, and HRMS. The synthesized triazoles were evaluated for in vitro antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, Candida albicans, and Aspergillus niger . Compounds3m and3q displayed appreciable broad spectrum antimicrobial activity against tested microbial strains. The nanoformulations of compounds3m and3q were also prepared and examined against one bacterial strain and one fungal strain. GRAPHICAL ABSTRACT: