Alarmin high mobility group box-1 in maternal serum as a potential biomarker of chorioamnionitis-associated preterm birth. (1st February 2017)

• Record Type: Journal Article
• Authors: Qiu, Xiao-Yuan; Sun, Lu; Han, Xue-Ling; Chang, Ying; Cheng, Lan; Yin, Li-Rong
• Is Part Of: Gynecological endocrinology. Volume 33:Number 2(2017)
• Page Start: 128
• Page End: 131
• Publication Date: 2017-02-01
• Subjects: Alarmin -- chorioamnionitis -- HMGB1 -- maternal serum -- preterm birth; Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.1080/09513590.2016.1214260
• Languages: English
• ISSNs: 0951-3590

Abstract

Abstract: Chorioamnionitis is associated with an increased risk of spontaneous preterm birth. The aim of this study was to investigate the serum levels of high mobility group box-1 (HMGB1) in pregnancies with histological chorioamnionitis (HCA)-associated preterm labor (PTL) with intact membranes or preterm premature rupture of membranes (PPROM), and to access the role of serum HMGB1 in HCA and HCA-associated PTL. A total of 190 pregnant women were enrolled in this study: PLT patients with ( n = 28) or without HCA ( n = 36), PPROM patients with ( n = 26) or without HCA ( n = 65), and non-HCA PTL controls ( n = 35). Maternal serum levels of HMGB1 were measured by enzyme-linked immunosorbent assay. Serum HMGB1 levels were significantly higher in PTL or PPROM patients than in control group ( p < 0.01, respectively). The PPROM patients also exhibited higher serum HMGB1 levels compared to PTL patients ( p = 0.015). HCA patients were characterized by significantly increased levels of serum HMGB1 when compared with non-HCA patients ( p < 0.01). Therefore, maternal serum HMGB1 may become a potential biomarker of HCA and HCA-associated PTL.