Dietary intake of magnesium-l-threonate alleviates memory deficits induced by developmental lead exposure in rats. Issue 14 (24th January 2017)

• Record Type: Journal Article
• Authors: Lou, Zhi-Yi; Chen, Weiheng; Xue, Wei-zhen; Ding, Jin-Jun; Yang, Qian-Qian; Wang, Hui-Li
• Is Part Of: RSC advances. Volume 7:Issue 14(2017)
• Page Start: 8241
• Page End: 8249
• Publication Date: 2017-01-24
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra26959a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Elevation of brain magnesium enhances cognitive capacity. Abstract : Elevation of brain magnesium enhances cognitive capacity. Chronic lead (Pb) exposure has been implicated in the impairment of cognition. Whether elevation of brain magnesium rescues the impairment of memory by chronic Pb exposure is still unclear. Here we investigated the effect and possible mechanisms of chronic dietary intake of magnesium-l -threonate (MgT) on impaired spatial memory by chronic developmental Pb exposure in rats. We found that MgT rescued impaired spatial memory ability in Pb-exposed rats. This positive effect is relative to increasing dendritic spine density and the expression of NR2A and GluR1.