Design and synthesis of dual probes for detection of metal ions by LALDI MS and fluorescence: application in Zn(ii) imaging in cells. Issue 12 (23rd January 2017)

• Record Type: Journal Article
• Authors: Arundhoti Mandal, ; Maity, Asim; Bag, Swarnendu; Bhattacharya, Prabuddha; Das, Amit K.; Basak, Amit
• Is Part Of: RSC advances. Volume 7:Issue 12(2017)
• Page Start: 7163
• Page End: 7169
• Publication Date: 2017-01-23
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra27302e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A Label-Assisted Laser Desorption/Ionization (LALDI) technique has recently been applied to the detection of metal ions through a time of flight (TOF) mass spectrometric measurement. Abstract : A Label-Assisted Laser Desorption/Ionization (LALDI) technique has recently been applied to the detection of metal ions through a time of flight (TOF) mass spectrometric measurement. In this paper, we report the synthesis of two terpyridine based ligandsL1 andL2 containing a pyrene moiety. The presence of the latter helped the ligand metal complex to desorb from the surface and ionize upon laser irradiation and finally show up in the TOF MS. Both ligands were able to detect Zn 2+, Ni 2+ and Co 2+ ions while Cu 2+, Fe 2+ and Mg 2+ remained LDI silent. Complexation with the ligands also caused a red fluorescence only with Zn 2+ ions that allowed Zn 2+ imaging in cells. Thus the pyrene moiety acted as a dual probe for metal ion detection exploiting both LALDI MS and fluorescence techniques.