NHC-catalyzed [4 + 2] annulation of 2-bromo-2-enals with acylhydrazones: enantioselective synthesis of δ-lactams. Issue 4 (9th January 2017)

• Record Type: Journal Article
• Authors: Sun, Baomin; Gao, Lijiu; Shen, Shide; Yu, Chenxia; Li, Tuanjie; Xie, Yuanwei; Yao, Changsheng
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 4(2017)
• Page Start: 991
• Page End: 997
• Publication Date: 2017-01-09
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob02253g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An asymmetric assembly of δ-lactams was realized via the NHC-catalyzed formal [4 + 2] annulation of acylhydrazones and 2-bromo-2-enals bearing γ-H. Abstract : An asymmetric assembly of δ-lactams was realized via the NHC-catalyzed formal [4 + 2] annulation of acylhydrazones and 2-bromo-2-enals bearing γ-H. The advantages of this protocol include high enantioselectivity, good yields, mild reaction conditions and potential biological significance of the final products.