Inner salt-shaped small molecular photosensitizer with extremely enhanced two-photon absorption for mitochondrial-targeted photodynamic therapy. Issue 10 (19th January 2017)

• Record Type: Journal Article
• Authors: Hu, Wenbo; He, Tingchao; Jiang, Rongcui; Yin, Jun; Li, Lin; Lu, Xiaomei; Zhao, Hui; Zhang, Lei; Huang, Ling; Sun, Handong; Huang, Wei; Fan, Quli
• Is Part Of: Chemical communications. Volume 53:Issue 10(2017)
• Page Start: 1680
• Page End: 1683
• Publication Date: 2017-01-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc09473b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An inner salt-shaped small-molecular photosensitizer with unprecedentedly strong two-photon absorption was developed for highly efficient two-photon photodynamic therapy via a mitochondrial apoptosis pathway. Abstract : Herein, we experimentally and theoretically demonstrate an unprecedentedly enhanced two-photon absorption in a small organic molecule by a simple introduction of an inner salt-shaped structure. Moreover, such an inner salt-shaped small molecule also exhibits superior singlet oxygen quantum yield and fascinating structure-inherent mitochondrial-targeting ability for highly efficient two-photon photodynamic therapy via a mitochondrial apoptosis pathway.