A computational mechanistic investigation into the reduction of Pt(iv) prodrugs with two axial chlorides by biological reductants. Issue 8 (12th January 2017)
- Record Type:
- Journal Article
- Title:
- A computational mechanistic investigation into the reduction of Pt(iv) prodrugs with two axial chlorides by biological reductants. Issue 8 (12th January 2017)
- Main Title:
- A computational mechanistic investigation into the reduction of Pt(iv) prodrugs with two axial chlorides by biological reductants
- Authors:
- Ejehi, Zeinab
Ariafard, Alireza - Abstract:
- Abstract : The reduction of the Pt(iv ) prodrugs with two axial chlorido ligands by biological reductants does not always proceed via the chloride-bridge inner-sphere mechanism. Abstract : It is widely reported that the Pt(iv ) prodrugs with two axial chlorido ligands are reduced by biological reductants via a chloride-bridged inner-sphere mechanism. By contrast, in this contribution, we demonstrate that although this approach might be true for the reductants with sulphur donors, the reduction by ascorbates preferentially occurs via an outer sphere mechanism.
- Is Part Of:
- Chemical communications. Volume 53:Issue 8(2017)
- Journal:
- Chemical communications
- Issue:
- Volume 53:Issue 8(2017)
- Issue Display:
- Volume 53, Issue 8 (2017)
- Year:
- 2017
- Volume:
- 53
- Issue:
- 8
- Issue Sort Value:
- 2017-0053-0008-0000
- Page Start:
- 1413
- Page End:
- 1416
- Publication Date:
- 2017-01-12
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c6cc07834f ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 2288.xml