Selective reduction of IFN-γ single positive mycobacteria-specific CD4+ T cells in HIV-1 infected individuals with latent tuberculosis infection. (December 2016)

• Record Type: Journal Article
• Authors: Riou, Catherine; Bunjun, Rubina; Müller, Tracey L.; Kiravu, Agano; Ginbot, Zekarias; Oni, Tolu; Goliath, Rene; Wilkinson, Robert J.; Burgers, Wendy A.
• Is Part Of: Tuberculosis. Volume 101(2016)
• Page Start: 25
• Page End: 30
• Publication Date: 2016-12
• Subjects: HIV -- Mycobacterium tuberculosis -- LTBI -- PPD -- BCG -- ESAT-6/CFP-10 -- Polyfunction -- Memory; 616.995
• DOI: 10.1016/j.tube.2016.07.018
• Languages: English
• ISSNs: 1472-9792

Abstract

Summary: HIV-1 is recognized to increase the risk for tuberculosis even before CD4+ T cell deficiency is profound. To better understand how HIV-1 alters immunity to latent tuberculosis, we compared the magnitude and functional profile of mycobacteria-specific CD4+ T cells between HIV-uninfected and HIV-infected individuals, using flow cytometry. In HIV-1 infection, IFN-γ single positive mycobacteria-specific CD4+ T cells were decreased, while the frequency of polyfunctional cells (IFN-γ+IL-2+TNF-α+) remained unchanged. Moreover, the proportion of IFN-γ single positive cells correlated inversely with viral replication. Our results suggest that HIV-1 affects mycobacteria-specific cells differentially, depending on their functional capacity.