Lateralization of intrinsic frontoparietal network connectivity and symptoms in schizophrenia. (28th February 2017)

• Record Type: Journal Article
• Authors: Son, Shuraku; Miyata, Jun; Mori, Yasuo; Isobe, Masanori; Urayama, Shin-ichi; Aso, Toshihiko; Fukuyama, Hidenao; Murai, Toshiya; Takahashi, Hidehiko
• Is Part Of: Psychiatry research. Volume 260(2017)
• Page Start: 23
• Page End: 28
• Publication Date: 2017-02-28
• Subjects: rsfMRI resting-state functional magnetic resonance imaging -- ROI region-of-interest -- ICA independent component analysis -- FPN frontoparietal network -- SCID-P Structured Clinical Interview for DSM-Ⅳ Axis Ⅰ Disorders Patients Edition, Version 2.0 -- JART the Japanese Version of the National Adult Reading Test -- PANSS Positive and Negative Syndrome Scale -- SCID-NP Structured Clinical Interview for DSM-Ⅳ Axis Ⅰ Disorders - Non-patient Edition, Version 2.0 -- 3D-MPRAGE 3-dimensional magnetization-prepared rapid gradient echo -- EPI echo planar imaging -- TE echo time -- TR repetition time -- FOV field of view -- MELODIC Multivariate Exploratory Linear Optimized Decomposition into Independent Components -- FWHM full width at half maximum -- LI laterality index, HP, haloperidol -- Hc healthy control group -- Sc schizophrenia group; Independent component analysis -- Resting state fMRI -- Laterality -- Asymmetry -- Positive symptoms -- Depressive symptoms; Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2016.12.007
• Languages: English
• ISSNs: 0925-4927

Abstract

Abstract: It has been frequently reported that schizophrenia patients have reduced functional lateralization in the areas related to language processing. Furthermore, there is evidence supporting that schizophrenia patients have disrupted functional connectivity in the bilateral frontoparietal networks (FPNs), of which the left is strongly associated with a cognition-language paradigm, using resting-state functional magnetic resonance imaging (rsfMRI). To examine the laterality of resting-state functional connectivity in schizophrenia, we investigated the bilateral FPNs. We investigated 41 schizophrenia and 35 healthy participants using independent component analysis for rsfMRI. We extracted mean connectivity values of both left and right FPNs and calculated their laterality index by (left - right)/(left + right). Subsequently, we investigated group differences of these values and the correlation between these values and symptoms. In schizophrenia, mean connectivity values of both left and right FPNs were significantly lower than in healthy controls, whereas their laterality indices were not significantly different. However, correlation analyses revealed that the laterality index was negatively correlated with positive symptoms, and that mean connectivity of left FPN was negatively correlated with depressive symptoms in schizophrenia. Our results suggest that language-related networks and their laterality might be one of the neural correlates of schizophrenia symptoms. Highlights: Laterality of bilateral FPN connectivity was not different in schizophrenia. It was negatively correlated with positive symptoms in schizophrenia. Left one was negatively correlated with depressive symptoms in schizophrenia.