Reduced ADAMTS-13 level negatively correlates with inflammation factors in plasma of acute myeloid leukemia patients. (February 2017)

• Record Type: Journal Article
• Authors: Liu, Chen; Zhao, Lei; Zhao, Jingzhong; Xu, Qinzhu; Song, Ying; Wang, Hui
• Is Part Of: Leukemia research. Volume 53(2017:Feb.)
• Page Start: 57
• Page End: 64
• Publication Date: 2017-02
• Subjects: AML acute myeloid leukemia -- APTT activated partial thromboplastin time -- CR complete remission -- CRP C-reactive protein -- DIC disseminated intravascular coagulation -- ELISA enzyme-linked immunosorbent assay -- FAB French-American-British classification -- IL interleukin -- ISTH International Society of Thrombosis and Hemostasis -- OR Odds Ratio -- PT prothrombin time -- TNFα tumor necrosis factor α -- TTP thrombotic thrombocytopenic purpura -- vWF von Willebrand factor -- WBC white blood cells; ADAMTS-13 -- AML -- Infection -- Inflammation -- DIC; Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2016.12.004
• Languages: English
• ISSNs: 0145-2126

Abstract

Highlights: Reduced ADAMTS-13 level in plasma of AML patients. AML patients with infection possessed lower level of ADAMTS-13. ADAMTS-13 negatively correlates with inflammation factors in AML patients. AML patients accompanying DIC possessed lower levels of ADAMTS-13. Abstract: ADAMTS-13 is crucial for maintaining the normal size of vWF. Besides thrombotic thrombocytopenic purpura (TTP), decreased ADAMTS-13 had also been reported in patients with malignancy. However, the knowledge of expression and potential role of ADAMTS-13 in hematological malignancies is still limited. We measured and compared ADAMTS-13 levels in the plasma of 82 acute myeloid leukemia (AML) patients and 34 healthy controls and found that AML patients possessed lower ADAMTS-13 than controls. AML patients with infections possessed lower level of ADAMTS-13 than patients without infections and ADAMTS-13 levels were negatively correlated with C-reactive protein(CRP), IL-6, TNFα and IL-1β. Furthermore, high risk AML patients are with lower ADAMTS-13 than patients with low risk. ADAMTS-13 negatively correlated with ISTH scores and patients accompanying DIC possessed lower ADAMTS-13.Multivariate analyses proved that low level of ADAMTS-13 is an independent risk factor for AML outcome. To conclude, ADAMTS-13 levels are decreased in plasma of AML patients and the level of ADAMTS-13 is related to inflammation and infection of AML patients. Besides, low ADAMTS-13 level is one potential risk factor for AML patients.