Aplastic Anemia and MDS International Foundation (AAMDSIF): Bone marrow failure disease scientific symposium 2016. (February 2017)

• Record Type: Journal Article
• Authors: Zeidan, Amer M.; Battiwalla, Minoo; Berlyne, Deborah; Winkler, Thomas
• Is Part Of: Leukemia research. Volume 53(2017:Feb.)
• Page Start: 8
• Page End: 12
• Publication Date: 2017-02
• Subjects: BMFS bone marrow failure syndromes -- HSC hematopoietic stem cell -- BM bone marrow -- AML acute myelogenous leukemia -- MDS myelodysplastic syndromes -- LSC leukemia stem cell -- CHIP clonal hematopoiesis of indeterminate potential -- MDSCs myeloid derived suppressor cells -- LR lower risk -- CHIP clonal hematopoiesis of indeterminate potential -- TGF transforming growth factor -- HMA hypomethylating agent -- SCT stem cell transplantation -- RBC red blood cell -- HMA hypomethylating agent -- RBC red blood cell -- ATG antithymocyte globulin -- PNH paroxysmal nocturnal hemoglobinuria -- MUD matched unrelated donor -- IST immunosuppressive therapy; Bone marrow failure -- Myelodysplastic syndromes -- Aplastic anemia -- Immunobiology -- Hematopoietic stem cell transplantation -- Novel therapies; Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2016.11.011
• Languages: English
• ISSNs: 0145-2126

Abstract

Abstract: Patients with acquired and inherited bone marrow failure syndromes (BMFS) have ineffective hematopoiesis due to impairments of the hematopoietic stem cell compartment. Common manifestations of BMFS include varying degrees of peripheral blood cytopenias and, sometimes, progression to acute myelogenous leukemia. Research efforts have been made all over the world to improve understanding of the pathogenesis of these diseases and their clinical implications. The Aplastic Anemia and MDS International Foundation (AAMDSIF) is an independent nonprofit organization whose mission is to help patients and family members cope with BMFS. Here, we summarize recent scientific discoveries in several BMFS that were presented at the fifth International Bone Marrow Failure Disease Scientific Symposium 2016 that AAMDSIF sponsored on March 17–18, 2016, in Rockville, Maryland.