Cytokine profiles in patients with toxoplasmic lymphadenitis in the setting of pregnancy. (February 2017)

• Record Type: Journal Article
• Authors: Pomares, Christelle; Holmes, Tyson H.; Estran, Remy; Press, Cynthia J.; Ramirez, Raymund; Talucod, Jeanne; Maecker, Holden; Rosenberg-Hasson, Yael; Montoya, Jose G.
• Is Part Of: Cytokine. Volume 90(2017)
• Page Start: 14
• Page End: 20
• Publication Date: 2017-02
• Subjects: Toxoplasmic lymphadenitis -- Acute infection -- Serology -- Cytokine -- Pregnancy; Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2016.09.021
• Languages: English
• ISSNs: 1043-4666

Abstract

Highlights: Levels of some cytokines differ with presence/absence of toxoplasmic lymphadenitis. Dye test titers differ with presence/absence of toxoplasmic lymphadenitis. With toxoplasmic lymphadenitis, levels of some cytokines vary with pregnancy status. Abstract: Introduction: Majority of Toxoplasma gondii infections are benign and asymptomatic; however, some patients experience toxoplasmic lymphadenitis (TL). Factors associated as to whether infection will be symptomatic or not are unknown. Methods: Dye test titers of patients with acute toxoplasmosis (pregnant and not pregnant) with TL (TL+) were compared with those in patients with asymptomatic acute infection (TL−). Additionally, mean levels of 62 serum cytokines were compared between TL+ and TL− pregnant women and between TL+ pregnant and non-pregnant women. Results: During acute infection, mean dye test titer was higher in TL+ than in TL− patients (p = 0.021). In addition, out of 62 cytokines, CXCL9 and CXCL10 levels were higher (p < 0.05) and resistin mean levels were lower (p < 0.05) in pregnant women with TL+ compared to TL−. Among patients with TL+, levels of VCAM1 and CCL2 were lower (p < 0.05) in pregnant women than in non-pregnant women. Conclusion: Here we report differences in dye test titers in patients with acute infection. Cytokine responses vary according to the presence of TL+ and to the pregnancy status. Factors underlying these differences are presently unknown and require further studies to define individual and combined roles of cytokines in TL+.