The evolutionary scenario of hepatocellular carcinoma in Italy: an update. (17th August 2016)

• Record Type: Journal Article
• Authors: Bucci, Laura; Garuti, Francesca; Lenzi, Barbara; Pecorelli, Anna; Farinati, Fabio; Giannini, Edoardo G.; Granito, Alessandro; Ciccarese, Francesca; Rapaccini, Gian Lodovico; Di Marco, Maria; Caturelli, Eugenio; Zoli, Marco; Borzio, Franco; Sacco, Rodolfo; Cammà, Calogero; Virdone, Roberto; Marra, Fabio; Felder, Martina; Morisco, Filomena; Benvegnù, Luisa; Gasbarrini, Antonio; Svegliati‐Baroni, Gianluca; Foschi, Francesco Giuseppe; Missale, Gabriele; Masotto, Alberto; Nardone, Gerardo; Colecchia, Antonio; Bernardi, Mauro; Trevisani, Franco
• Other Names: Biselli Maurizio investigator.; Caraceni Paolo investigator.; Cucchetti Alessandro investigator.; Domenicali Marco investigator.; Gramenzi Annagiulia investigator.; Magalotti Donatella investigator.; Napoli Lucia investigator.; Negrini Giulia investigator.; Piscaglia Fabio investigator.; Serra Carla investigator.; Tovoli Francesco investigator.; Marafatto Filippo investigator.; Murer Francesca investigator.; Peserico Giulia investigator.; Pozzan Caterina investigator.; Vanin Veronica investigator.; Moscatelli Alessandro investigator.; Pellegatta Gaia investigator.; Picciotto Antonino investigator.; Savarino Vincenzo investigator.; Poggio Paolo Del investigator.; Olmi Stefano investigator.; de Matthaeis Nicoletta investigator.; Balsamo Claudia investigator.; Vavassori Elena investigator.; Roselli Paola investigator.; Dell'Isola Serena investigator.; Ialungo Anna Maria investigator.; Rastrelli Elena investigator.; Barcellona Maria Rosa investigator.; Cabibbo Giuseppe investigator.; Costantino Andrea investigator.; Maida Marcello investigator.; Affronti Andrea investigator.; Mega Andrea investigator.; Rinninella Emanuele investigator.; Mismas Valeria investigator.; Dall'Aglio Anna Chiara investigator.; Feletti Valentina investigator.; Lanzi Arianna investigator.; Cappa Federica Mirici investigator.; Neri Elga investigator.; Stefanini Giuseppe Francesco investigator.; Tamberi Stefano investigator.; Biasini Elisabetta investigator.; Porro Emanuela investigator.; Guarino Maria investigator.; Gemini Stefano investigator.; Schiadà Laura investigator.; Chiaramonte Maria investigator.; Marchetti Fabiana investigator.; Valerio Matteo investigator.; Cappelli Alberta investigator.; Golfieri Rita investigator.; Mosconi Cristina investigator.; Renzulli Matteo investigator.; Coccoli Piero investigator.; Zamparelli Marco Sanduzzi investigator.; Aburas Sami investigator.; Inghilesi Andrea Lorenzo investigator.;
• Is Part Of: Liver international. Volume 37:Number 2(2017)
• Page Start: 259
• Page End: 270
• Publication Date: 2016-08-17
• Subjects: epidemiology -- hepatocellular carcinoma -- survival -- treatment; Liver -- Periodicals; Liver -- Diseases -- Periodicals; 616.362
• DOI: 10.1111/liv.13204
• Languages: English
• ISSNs: 1478-3223

Abstract

Abstract : Background & Aims: Epidemiology of hepatocellular carcinoma is changing worldwide. This study aimed at evaluating the changing scenario of aetiology, presentation, management and prognosis of hepatocellular carcinoma in Italy during the last 15 years. Methods: Retrospective analysis of the ITA.LI.CA (Italian Liver Cancer) database including 5192 hepatocellular carcinoma patients managed in 24 centres from 2000 to 2014. Patients were divided into three groups according to the date of cancer diagnosis (2000–2004, 2005–2009 and 2010–2014). Results: The main results were as follows: (i) progressive patient aging; (ii) progressive expansion of non‐viral cases and, namely, of "metabolic" hepatocellular carcinomas; (iii) increasing proportion of hepatocellular carcinoma diagnosed during a correct (semi‐annual) surveillance programme; (iv) favourable cancer stage migration; (v) increased use of radiofrequency ablation to the detriment of percutaneous ethanol injection; (vi) improved outcomes of ablative and transarterial treatments; (vii) improved overall survival (adjusted for the lead time in surveyed patients), particularly after 2009, of both viral and non‐viral patients presenting with an early‐ or intermediate‐stage hepatocellular carcinoma. Conclusions: During the last 15 years several aetiological and clinical features of hepatocellular carcinoma patients have changed, as their management. The observed improvement of overall survival was owing both to the wider use of semi‐annual surveillance, expanding the proportion of tumours that qualified for curative treatments, and to the improved outcome of loco‐regional treatments.