Uterine angioleiomyoma in an African green monkey (Chlorocebus aethiops sabaeus). Issue 1 (8th November 2016)

• Record Type: Journal Article
• Authors: Valentine, Matthew John; Beierschmitt, Amy; DeLay, Josepha; Callanan, John Joseph
• Is Part Of: Journal of medical primatology. Volume 46:Issue 1(2017)
• Page Start: 9
• Page End: 12
• Publication Date: 2016-11-08
• Subjects: immunohistochemistry -- neoplasia -- non‐human primate -- uterus -- vascular leiomyoma; Primates -- Periodicals; Primates -- Diseases -- Periodicals; Medicine, Experimental -- Periodicals; 616.02738
• DOI: 10.1111/jmp.12248
• Languages: English
• ISSNs: 0047-2565

Abstract

Abstract: Background: A uterine neoplasm was observed, as an incidental finding, during post‐mortem examination of a 26‐year‐old female multiparous African green monkey ( Chlorocebus aethiops sabaeus ). The intramural, expansile, 2 to 3 cm well‐demarcated, dark‐red, nodular neoplasm was located on the anterior uterine body (corpus) wall. Methods: The mass was examined by light microscopy and by immunohistochemistry. Results: The mass was confirmed as a cavernous uterine angioleiomyoma (syn. vascular leiomyoma) characterized by abundant intratumoural vasculature lined by Factor VIII‐positive endothelial cells and surrounded by smooth muscle actin‐positive cell proliferations. Conclusion: Angioleiomyoma sharing the characteristics of intramural human cavernous uterine angioleiomyoma should be considered in the differential diagnosis of uterine tumours in non‐human primates.